JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2024  1,200
2023  1,500
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 59(2025) N 3 p. 293-319; DOI 10.1134/S0026893325700013 Full Text

E.A. Chingizova1*, O.D. Novikova1, O.Yu. Portnyagina1, D.L. Aminin1

Components of Bacterial Cell Walls as Targets for Searching for New Antibacterial Compounds: Methods of Study

1Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok, 690022 Russia

*martyyas@mail.ru
Received - 2024-06-05; Revised - 2024-11-21; Accepted - 2024-11-22

In the modern-day world, antibiotic resistance is one of the most serious threats to both human health and food security. Finding new ways to prevent and overcome the formation of pathogen resistance to antibiotics is an extremely important and urgent task in modern medical science. All bacteria, except myco-plasmas, have cell walls in which various enzymes, receptors, transporters, channels, and antigens are located. This review is devoted to describing the structure of the major elements of bacterial cell walls and the enzymes involved in their biosynthesis, and is used as molecular targets for screening and selection of new effective antibiotics. Special attention has been paid to methods for studying the functional activity and inhibition of these targets. In addition, this review describes the functional characteristics of pore-forming proteins in the outer membrane of Gram-negative bacteria and the molecular mechanisms of antibiotic penetration through porin channels. Analysis of the structure and functional features of the targets of different classes of antibiotics is the basis for developing new strategies to overcome bacterial resistance.

antibiotics, targets, bacterial cell wall, methods, enzymes, porins



JMB-FOOTER RAS-JOURNALS