JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2024  1,200
2023  1,500
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 59(2025) N 3 p. 348-364; DOI 10.1134/S0026893325700049 Full Text

A.M. Burdennyy1,2*, V.I. Loginov1,3, M.V. Fridman4, N.E. Kushlinskii5, E.A. Braga1,3**

Small Nucleolar RNAs and Long Non-Coding RNAs of the SNHG Family in the Pathogenesis of Ovarian Cancer

1Research Institute of General Pathology and Pathophysiology, Moscow, 125315 Russia
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119334 Russia
3Bochkov Medical Genetic Research Center, Moscow, 115522 Russia
4Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 117971 Russia
5Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, 115522 Russia


*burdennyy@gmail.com
**eleonora10_45@mail.ru
Received - 2024-11-26; Revised - 2024-12-04; Accepted - 2024-12-05

The discovery of a class of long noncoding RNAs (lncRNAs), including lncRNAs of the small nucleolar RNA (snoRNA) host gene family, SNHG, has led to growing interest in the study of both snoRNAs themselves and the genes encoding them. Currently, of the 232 known snoRNA genes, only 32 have been confirmed to have lncRNAs. At the same time, a positive correlation has been shown between the expression of lncRNAs and snoRNAs encoded by a common host gene of the SNHG family. Thus, lncRNA of the SNHG1 gene correlates with snoRNAs SNORD22 and SNORD25-31, and lncRNA of the SNHG16 gene, with snoRNAs SNORD1A, SNORD1B, and SNORD1C. There is evidence that SNHG lncRNAs can participate in oncogenesis both through regulatory functions inherent to lncRNAs and by influencing ribosome biogenesis. At the same time, information has accumulated on the "extraribosomal" functions of snoRNAs. In addition to a brief excursion into the biological functions of snoRNAs and SNHG lncRNAs, we present a comprehensive review of data on the role of these two types of noncoding RNAs in the pathogenesis of ovarian cancer, the most insidious cancer of the female reproductive system. The influence of these regulatory RNAs on the main processes of ovarian oncogenesis, such as apoptosis, epithelial-mesenchymal transition, cell cycle control, and DNA methylation mechanisms in this type of cancer is considered. The prospects for clinical application of regulatory RNAs due to their influence on the level of drug resistance are also discussed.

snoRNA, lncRNA, SNHG family, competing endogenous RNA, microRNA, ovarian cancer, apoptosis, epithelial-mesenchymal transition, DNA methylation, DNA methyltransferase, ten-eleven translocation dioxygenases (TET)



JMB-FOOTER RAS-JOURNALS