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Vol 58(2024) N 4 p. 693-699; DOI 10.1134/S0026893324700274  J.V. Nikolenko1,2, M.M. Kurshakova2, D.V. Kopytova2, Y.A. Vdovina2, N.E. Vorobyova1, A.N. Krasnov1* The Drosophila Zinc Finger Protein CG9609 Interacts with the Deubiquitinating (DUB) Module of the SAGA Complex and Participates in the Regulation of Transcription 1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia2Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia *krasnov@genebiology.ru Received - 2023-11-17; Revised - 2023-12-12; Accepted - 2023-12-12 In previous studies, we found that the zinc finger proteins Su(Hw) and CG9890 interact with the Drosophila SAGA complex and participate in the formation of the active chromatin structure and transcription regulation. In this research, we discovered the interaction of the DUB module of the SAGA complex with another zinc finger protein, CG9609. ChIP-Seq analysis was performed, and CG9609 binding sites in the Drosophila genome were identified. Analysis of binding sites showed that they are localized predominantly at gene promoters. The CG9609 protein has been shown to be involved in the regulation of gene expression. CG9609, zinc fingers, transcription activation, DUB-module, SAGA complex |
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