JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2023  1,500
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 58(2024) N 2 p. 289-299; DOI 10.1134/S0026893324020055 Full Text

N.A. Tchurikov1*, A.A. Vartanian2, E.S. Klushevskaya1, I.R. Alembekov1, A.N. Kretova1, V.R. Chechetkin1, G.I. Kravatskaya1, V.S. Kosorukov2, Y.V. Kravatsky1

Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
2Department of Experimental Diagnosis and Therapy of Tumors, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, 115478 Russia


*tchurikov@eimb.ru
Received - 2023-09-01; Revised - 2023-10-17; Accepted - 2023-10-17

Multiple exogenous or endogenous factors alter gene expression patterns by different mechanisms that are poorly understood. We used RNA-Seq analysis in order to study changes in gene expression in melanoma cells that are capable of vasculogenic mimicry that is inhibited upon the action of an inhibitor of vasculogenic mimicry. Here, we show that the drug induces a strong upregulation of 50 genes that control the cell cycle and microtubule cytoskeleton coupled with a strong downregulation of 50 genes that control different cellular metabolic processes. We found that both groups of genes are simultaneously regulated by multiple sets of transcription factors. We conclude that one way for coordinated regulation of large groups of genes is regulation simultaneously by multiple transcription factors.

coordinated expression, melanoma, Matrigel, LCS1269 inhibitor, RNA-Seq, transcription factors, ACER2, TCAF2, KIF18A, NAV3, FGF13, NCKAP5



JMB-FOOTER RAS-JOURNALS