2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 57(2023) N 6 p. 1052-1069; DOI 10.1134/S0026893323060092 Full Text

N.D. Kondratenko1,2, L.A. Zinovkina3, R.A. Zinovkin1,2*

Transcription Factor NRF2 in Endothelial Functions

1Belozersky Institute of Physicochemical Biology, Moscow State University, Moscow, 119991 Russia
2Pirogov Russian National Research Medical University, Russian Clinical Research Center for Gerontology, Ministry of Health of the Russian Federation, Moscow, 129226 Russia
3Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, 119991 Russia

Received - 2023-04-16; Revised - 2023-05-11; Accepted - 2023-05-22

The transcription factor NRF2 is a major regulator of cell antioxidant defense. NRF2 is activated by various stimuli, such as oxidants and electrophiles, to induce transcription of a number of genes whose products are involved in xenobiotic metabolism and contribute to the reduction of oxidative stress. NRF2 is one of the key transcription factors that ensure the endothelial cell function. The endothelium is a cell layer that lines the lumens of blood vessels and performs various homeostatic functions, controlling migration of leukocytes, regulating thrombosis and vascular tone, and playing a role in angiogenesis. Endothelial dysfunction is often accompanied by inflammation and oxidative stress, which may lead to cell aging and cell death by apoptosis, necrosis, or ferroptosis. Endothelial dysfunction contributes to the development of diabetes and common cardiovascular disorders, such as hypertension and atherosclerosis. Many pathophysiological processes in the endothelium, including senile changes, are associated with decreased NRF2 activity, leading to inflammatory activation and decreasing activity of the cell antioxidant defense systems. Activation of the NRF2 signaling pathway generally contributes to the resolution of inflammation and oxidative stress. The review focuses on the role that NRF2 plays in basic functions of the endothelium in normal and pathological conditions. Advantages and disadvantages of NRF2 activation as a way to prevent and treat cardiovascular diseases are discussed additionally.

transcription factor NRF2, endothelium, aging, inflammation, oxidative stress, age-related changes, atherosclerosis, diabetes, angiogenesis