Vol 57(2023) N 5 p. 765-792; DOI 10.1134/S0026893323050096
N.A. Lunina1*, D.R. Safina1, S.V. Kostrov1
Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis1National Research Center "Kurchatov Institute", Moscow, 123182 Russia
Received - 2023-01-24; Revised - 2023-04-03; Accepted - 2023-04-03
Cancer-associated fibroblasts (CAFs) often form a major component of the tumor microenvironment (TMA), providing conditions for cancer cells to thrive. CAFs may contribute to tumor growth, invasion, metastasis, and resistance to therapy. However, clinical trials of treatment strategies targeting CAFs have largely failed. Moreover, there is evidence that CAFs are capable of inhibiting tumor development. The review considers the current data on the functional heterogeneity of CAFs and their bimodality in tumor development and progression. Understanding the tumor-promoting and tumor-inhibiting activities of CAFs can help to develop new diagnostic and therapeutic approaches.
cancer-associated fibroblasts, heterogeneity, markers, oncogenesis, metastasis, tumor stroma, tumor microenvironment