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Vol 56(2022) N 3 p. 469-473; DOI 10.1134/S0026893322030098 Full Text

A.A. Maslova1*, E.C. Matyugina1, E.Yu. Shustova2, V.P. Volok2, L.I. Kozlovskaya2,3, S.N. Kochetkov1, A.L. Khandazhinskaya1

New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
2Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Russian Academy of Sciences, Moscow, 108819 Russia
3Sechenov First Moscow State Medical University, Moscow, 119435 Russia

*maslova_anna94@mail.ru
Received - 2021-11-24; Revised - 2021-12-06; Accepted - 2021-12-07

The development of specific drugs against SARS-CoV-2 infection is a major challenge facing global science and healthcare. Despite numerous attempts, there are still no truly effective drugs. Currently, the main approach in the creation of drugs against COVID-19 is repurposing, i.e., re-profiling existing drugs approved for medical use, for example, the use of a drug for the treatment of Ebola-Remdesivir, and the use of a drug for the treatment of influenza-Favipiravir. However, it is already obvious that these drugs are not specific enough nor effective enough. Another promising approach is the creation of new molecules, but it should be noted immediately that implementation requires much more time and costs. However, the search for new SARS-CoV-2 specific antiviral agents continues. The aim of our work was the creation of new 5-substituted uridine derivatives as potential inhibitors of coronavirus RNA-dependent RNA polymerase. The substances were obtained in high yields by the Suzuki-Miyaura reaction and characterized using modern physicochemical methods. However, testing of their antiviral activity against SARS-CoV-2 did not reveal a significant inhibitory effect.

coronavirus, SARS-CoV-2, nucleoside analogs, fleximers, synthesis, Suzuki-Miyaura reaction



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