|
Vol 55(2021) N 6 p. 773-785; DOI 10.1134/S0026893321050113  A.A. Shulgin1,2*, T.D. Lebedev1, V.S. Prassolov1, P.V. Spirin1 Plasmolipin and Its Role in Cell Processes 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia2Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, 141701 Russia *ashu69@mail.ru Received - 2021-03-04; Revised - 2021-03-26; Accepted - 2021-04-05 The mechanisms involved in the origin and development of malignant and neurodegenerative diseases are an important area of modern biomedicine. A crucial task is to identify new molecular markers that are associated with rearrangements of intracellular signaling and can be used for prognosis and the development of effective treatment approaches. The proteolipid plasmolipin (PLLP) is a possible marker. PLLP is a main component of the myelin sheath and plays an important role in the development and normal function of the nervous system. PLLP is involved in intracellular transport, lipid raft formation, and Notch signaling. PLLP is presumably involved in various disorders, such as cancer, schizophrenia, Alzheimer's disease, and type 2 diabetes mellitus. PLLP and its homologs were identified as possible virus entry receptors. The review summarizes the data on the PLLP structure, normal functions, and role in diseases. proteolipids, neurodegenerative disorders, Notch signaling, SNARE, MARVEL, intracellular transport, lipid rafts, ion channels |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
