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Vol 55(2021) N 5 p. 683-704; DOI 10.1134/S0026893321040038 Full Text

E.I. Deryusheva1*, A.V. Machulin2, O.V. Galzitskaya3,4**

Structural, Functional, and Evolutionary Characteristics of Proteins with Repeats

1Institute of Biological Instrumentation, Pushchino Biological Research Center, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia
2Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Biological Research Center, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia
3Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia
4Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia

*evgenia.deryusheva@gmail.com
**ogalzit@vega.protres.ru
Received - 2021-03-16; Revised - 2021-03-29; Accepted - 2021-03-29

The review summarizes and systematizes the data on the classification, taxonomic distribution, structural features, and functions of proteins with structural repeats. Modern approaches to the identification of structural repeats in proteins are considered. Features of specialized databases of protein domains are described. The review discusses the prospects of using repeat-containing proteins as scaffolds for drug design. The role of proteins with structural repeats in the pathogenesis of various diseases is considered. Various modern approaches to understanding the mechanisms of the evolutionary development of proteins with repeats are described and analyzed.

structural domains, structural repeats, molecular functions, evolution



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