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Vol 55(2021) N 4 p. 589-603; DOI 10.1134/S0026893321030110 Full Text

F. Suo1, M. Pan1, Y. Li1, Q. Yan1, H. Hu1, L. Hou1*

Mesenchymal Stem Cells Cultured in 3D System Inhibit Non-small Cell Lung Cancer Cells Through p38 MAPK and CXCR4/AKT Pathways by IL-24 Regulating

1College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, 100044 PR China

*llhou@bjtu.edu.cn
Received - 2020-06-07; Revised - 2020-08-17; Accepted - 2020-09-15

Non-small cell lung cancer (NSCLC) is prevalent worldwide and has a high mortality rate. Even if mesenchymal stem cells (MSCs) are suggested as cancer treatment, the studies of their effects on NSCLC cells contradict each other, mainly due to utilization of two-dimensional (2D) culture system. Three-dimensional (3D) culture systems resemble tissue organization in vivo. Here we comprehensively explore the inhibitory effects of MSCs on NSCLC cells in a 3D culture system. We confirmed that the inhibitory effects of 3D-cultured MSCs (3D-MSCs) on the proliferation and migration of NSCLC cells are greater than that of the 2D-cultured MSCs. 3D-MSCs overexpress IL-24, which serve as the key factor enhancing antitumor effects of MSCs. In these cells, IL-24 affects p38 MAPK and CXCR4/AKT pathways. Overall, this study provides the support for use of MSCs in tumor.

mesenchymal stem cells, three-dimensional cell culture, interleukin-24, tumor inhibition, NSCLC



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