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Vol 55(2021) N 4 p. 501-506; DOI 10.1134/S002689332103002X Full Text

M.I. Airapetov1,2*, S.O. Eresko1,3, A.A. Lebedev1, E.R. Bychkov1, P.D. Shabanov1,4

Expression of Ghrelin Receptor GHS-R1a in The Brain (Mini Review)

1Institute of Experimental Medicine, St. Petersburg, 197376 Russia
2St. Petersburg State Pediatric Medical University, St. Petersburg, 194100 Russia
3St. Petersburg State Chemical Pharmaceutical University, St. Petersburg, 199034 Russia
4Kirov Military Medical Academy, St. Petersburg, 194044 Russia

*interleukin1b@gmail.com
Received - 2021-01-06; Revised - 2021-02-24; Accepted - 2021-02-25

The review presents data on the expression of ghrelin receptor GHS-R1a in the brain in model animals (Danio rerio, rodents, primates), and in the human brain. Studies show widespread localization of GHS-R1a in the brain, which indicates the involvement of the receptor in many physiological processes. Using various models, information has been obtained regarding the participation of the receptor in the regulation of the pro- and anti-inflammatory response, apoptosis and proliferation. It is known that the ghrelin receptor plays an important role in eating behavior and is also involved in the pathogenetic mechanisms of obesity, drug addiction, and alcoholism. With this in mind, research is underway with the use of various therapeutic agents (receptor agonists and antagonists) that can be used for the pharmacological correction of these pathological conditions. This review also presents hypothetical mechanisms of intracellular signaling, in which GHS-R1a may participate; however, a complete understanding of these mechanisms has not yet been reached. The ghrelin intracellular pathways seem to be specific to brain region and, probably, also depend on the metabolic or stress status of the organism.

ghrelin, GHS-R1a, brain, Danio rerio, rodents, primates, humans



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