Vol 55(2021) N 2 p. 184-194; DOI 10.1134/S002689332102014X
A.K. Velichko1,2,3, S.V. Razin1, O.L. Kantidze1*
DNA Damage Response in Nucleoli1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia
2Sechenov First Moscow State Medical University, Moscow, 119146 Russia
3Center of Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia
Received - 2020-08-05; Revised - 2020-08-05; Accepted - 2020-08-12
Nucleoli, the largest subnuclear compartments, are formed around arrays of ribosomal gene repeats transcribed by RNA polymerase I. The primary function of nucleoli is ribosome biogenesis. Specific DNA damage response mechanisms exist to maintain the genomic stability of ribosomal repeats. Here, we provide a snapshot of our current understanding of processes involved in nucleolar DNA damage response. We discuss structure and function of ribosomal repeats, techniques developed for studying DNA damage response in nucleoli, as well as molecular mechanisms of DNA damage-induced repression of nucleolar transcription and nucleoli reorganization.
DNA repair, transcription, ribosomal DNA, nucleolus