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Vol 54(2020) N 5 p. 633-638; DOI 10.1134/S0026893320050106 Full Text

K.A. Tatosyan1, L.S. Zinevich2, D.E. Demin1,3, A.M. Schwartz1*

Functional Characteristics of Long Noncoding RNAs Containing Sequences of Mobile Genetic Elements

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
2Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334 Russia
3Moscow Institute of Physics and Technology, Dolgoprudny, Moscow oblast, 141701 Russia

*shvarec@yandex.ru
Received - 2020-04-21; Revised - 2020-04-21; Accepted - 2020-04-27

Long nonconding RNAs (lncRNAs) perform a variety of functions: they are involved in chromatin organization, regulation of gene expression at the transcriptional and post-transcriptional levels, and regulation of activity and stability of some proteins. The majority of known lncRNAs contain sequences of mobile genetic elements (MGEs) in a sense or antisense orientation. According to several studies, MGE may serve as functional modules responsible for interactions between the lncRNA and certain proteins, DNA regions, or other RNAs. The available data make it possible to describe groups of lncRNAs that possess common structural features and contain certain MGEs and to predict the characteristics of new lncRNAs. The review summarizes the data on the role that MGE sequences play in lncRNA functions.

long noncoding RNA, mobile genetic element, SINE, Alu repeat



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