Vol 54(2020) N 5 p. 623-632; DOI 10.1134/S0026893320050039
D.V. Glazkova1,2, F.A. Urusov1,2*, E.V. Bogoslovskaya1, G.A. Shipulin1
Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection1Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal Medical-Biological Agency of the Russian Federation, Moscow, 119992 Russia
2Izmerov Research Institute of Occupational Health, Moscow, 105275 Russia
Received - 2020-03-19; Revised - 2020-04-14; Accepted - 2020-04-16
It is commonly known that the antiviral activity of the TRIM5α protein, the intracellular retrovirus restriction factor, underlies the resistance of the Old World monkeys to HIV-1. This fact suggests that TRIM5α can potentially be used to cure HIV-1 infection in humans. The present review considers the mechanisms of HIV-1 replication inhibition by the TRIM5a protein and the prospects for using it in gene therapy of HIV infection.
TRIM5α, HIV-1, gene therapy