JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 54(2020) N 4 p. 485-502; DOI 10.1134/S0026893320040159 Full Text

K.A. Tatosyan1, I.G. Ustyantsev1, D.A. Kramerov1*

RNA Degradation in Eukaryotic Cells

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia

*kramerov@eimb.ru
Received - 2020-03-16; Revised - 2020-03-16; Accepted - 2020-03-19

RNA is a crucial component of every living organism and is necessary for gene expression and its regulation in the cell. Mechanisms of RNA synthesis (especially mRNA synthesis) were a subject of extensive study for a long time. More recently, RNA degradation pathways began to be considered as equally important part of eukaryotic cell metabolism. These pathways have been studied intensely, and ample information accumulated about RNA degradation systems and their role in cell life. It is currently obvious that RNA decay is of no less importance as RNA synthesis and contributes to regulating the RNA level in the cell. The review considers the main RNA degradation enzymes, the decay pathways of various coding and non-coding RNAs, the mechanisms providing RNA quality control in the nucleus and cytoplasm, and certain structural elements responsible for RNA stability or short life in the cell.

RNA decay, exosomes, exonucleases, endonucleases, RNA stability, non-coding RNA, RNA quality control



JMB-FOOTER RAS-JOURNALS