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YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
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2016  0,799
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2013  0,739
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2006  0,330
2005  0,435
2004  0,623
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2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 54(2020) N 2 p. 249-255; DOI 10.1134/S0026893320020065 Full Text

E.S. Kolegova1*, G.V. Kakurina1, D.N. Kostromitskiy2, A.Yu. Dobrodeev1, I.V. Kondakova1

Increases in mRNA and Protein Levels of the Genes for the Actin-Binding Proteins Profilin, Fascin, and Ezrin Promote Metastasis in Non-Small Cell Lung Cancer

1Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634009 Russia
2Tomsk Regional Oncology Center, Tomsk, 634009 Russia

*elenakolegowa@mail.ru
Received - 2019-06-19; Revised - 2019-09-09; Accepted - 2019-09-17

The actin-binding proteins profilin, fascin, and ezrin were tested for involvement in metastasis of non-small cell lung cancer (NSCLC). The levels of the PFN1, FSCN1, and EZR mRNAs and respective proteins were determined by real-time PCR and Western blotting; tumor and adjacent normal lung tissue samples were obtained from 46 NSCLC patients. Patients with lymphatic metastasis had higher expression levels of the profilin, fascin, and ezrin mRNAs and the profilin and fascin proteins. Both mRNA and protein expression levels increased in patients with distant metastasis. The molecules may serve as predictors to evaluate the prognosis in NSCLC.

actin-binding proteins, profilin, fascin, ezrin, metastasis, non-small cell lung cancer



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