Vol 48(2014) N 3 p. 351-358; DOI 10.1134/S0026893314030169
O.E. Redina*, S.E. Smolenskaya, T.O. Abramova, A.L. Markel
Genetic Loci for Spleen Weight and Blood Pressure in ISIAH Rats with Inherited Stress-Induced Arterial HypertensionInstitute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia
Received - 2013-08-30; Accepted - 2013-12-20
Recently, the important role of the spleen's function in hypertension development was demonstrated. In this study, the genetic control of absolute and relative spleen weight was investigated to reveal the genetic loci common for spleen traits and for arterial blood pressure at rest and under the emotional stress conditions in ISIAH rats with inherited stress-induced arterial hypertension. The search for genetic loci for absolute and relative spleen weight was performed on 6-month-old F2 (ISIAH WAG) hybrid males derived from a cross of hypertensive ISIAH and normotensive WAG rats. One significant QTL mapped on chromosome 1 and 5 suggestive loci were found for relative spleen weight. Four suggestive loci were detected for absolute spleen weight. All detected loci were novel. The significant QTL on chromosome 1 was common for relative spleen weight and arterial blood pressure at rest and under the emotional stress conditions in ISIAH rats. The results suggest that the manifestation of the stress-sensitive arterial hypertension in ISIAH rats may be related to the changes in genetic control of the spleen function.
genetic control of arterial hypertension, QTL analysis, absolute and relative spleen weight, ISIAH rats