JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 48(2014) N 3 p. 351-358; DOI 10.1134/S0026893314030169 Full Text

O.E. Redina*, S.E. Smolenskaya, T.O. Abramova, A.L. Markel

Genetic Loci for Spleen Weight and Blood Pressure in ISIAH Rats with Inherited Stress-Induced Arterial Hypertension

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

*oredina@ngs.ru
Received - 2013-08-30; Accepted - 2013-12-20

Recently, the important role of the spleen's function in hypertension development was demonstrated. In this study, the genetic control of absolute and relative spleen weight was investigated to reveal the genetic loci common for spleen traits and for arterial blood pressure at rest and under the emotional stress conditions in ISIAH rats with inherited stress-induced arterial hypertension. The search for genetic loci for absolute and relative spleen weight was performed on 6-month-old F2 (ISIAH WAG) hybrid males derived from a cross of hypertensive ISIAH and normotensive WAG rats. One significant QTL mapped on chromosome 1 and 5 suggestive loci were found for relative spleen weight. Four suggestive loci were detected for absolute spleen weight. All detected loci were novel. The significant QTL on chromosome 1 was common for relative spleen weight and arterial blood pressure at rest and under the emotional stress conditions in ISIAH rats. The results suggest that the manifestation of the stress-sensitive arterial hypertension in ISIAH rats may be related to the changes in genetic control of the spleen function.

genetic control of arterial hypertension, QTL analysis, absolute and relative spleen weight, ISIAH rats



JMB-FOOTER RAS-JOURNALS