Vol 53(2019) N 3 p. 470-474; DOI 10.1134/S0026893319030063
O.V. Galzitskaya1*, G.S. Novikov2
An Overlap between Splicing Sites in RNA and Homo-Repeats in Human Proteins1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia
2Nanotechnology Research and Education Center, St. Petersburg National Academic Research University, St. Petersburg, 194021 Russia
Received - 2018-08-31; Revised - 2018-12-25; Accepted - 2018-12-28
Proteins with homo-repeats of more than 4 amino acid residues in length were examined to understand whether some splicing sites in pre-mRNA may be attributed to homo-repeats in human proteins. The human proteome was found to contain a total of 404 proteins with homo-repeats that account for at least one splicing site in pre-mRNA. Pre-mRNA splicing sites were more often found in the C-terminal part (67%) than in the middle orN-terminal part of a homo-repeat. Ten homo-repeats were identified to have two splicing sites per repeat. The repeats were lysine homo-repeats in all but one case.
homo-repeat, splicing, disease, disordered regions