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Vol 53(2019) N 3 p. 427-437; DOI 10.1134/S0026893319030129 Full Text

D.A. Mogilenko1,2,3, V.S. Shavva1, E.B. Dizhe1, S.V. Orlov1,2*

Characterization of Distal and Proximal Alternative Promoters of the Human ApoA-I Gene

1Institute of Experimental Medicine, St. Petersburg, 197376 Russia
2St. Petersburg State University, St. Petersburg, 199034 Russia
3Universite de Lille, Inserm, Institut Pasteur de Lille, U1011-EGID, Lille, 59000 France

*serge@iem.sp.ru
Received - 2018-12-09; Revised - 2018-12-29; Accepted - 2018-12-29

Human apolipoprotein A-I (ApoA-I) is a major structural and functional protein component of high-density lipoprotein (HDL). ApoA-I constitutes ~75% of the protein content of HDL. The main sites of ApoA-I synthesis in humans are the liver and the small intestine. The mechanisms that govern tissue-specific apoA-I transcription in tissues and organs other than the liver and the small intestine are poorly understood. It is known that the human apoA-I has two additional promoters, the proximal and the distal one. In this work these two alternative apoA-I promoters are characterized, their transcription start sites are mapped and their competition for apoA-Itranscription is demonstrated; the role of the alternative promoters in apoA-I expression in human cells and tissues other than hepatocytes and enterocytes is discussed.

apolipoprotein A-I, alternative promoter, promoter competition, transcription start site, human hepatoma cells HepG2



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