Vol 53(2019) N 3 p. 323-334; DOI 10.1134/S0026893319030154
B.V. Syomin1*, Y.V. Ilyin2
Virus-Like Particles as an Instrument of Vaccine Production1Institute for Statistical Studies and Economics of Knowledge (ISSEK), National Research University Higher School of Economics, Moscow, 101000 Russia
2Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
Received - 2018-09-28; Revised - 2018-12-19; Accepted - 2018-12-24
The paper discusses the techniques which are currently implemented for vaccine production based on virus-like particles (VLPs). The factors which determine the characteristics of VLP monomers assembly are provided in detail. Analysis of the literature demonstrates that the development of the techniques of VLP production and immobilization of target antigens on their surface have led to the development of universal platforms which make it possible for virtually any known antigen to be exposed on the particle surface in a highly concentrated form. As a result, the focus of attention has shifted from the approaches to VLP production to the development of a precise interface between the organism's immune system and the peptides inducing a strong immune response to pathogens or the organism's own pathological cells. Immunome-specified methods for vaccine design and the prospects of immunoprophylaxis are discussed. Certain examples of vaccines against viral diseases and cancers are considered.
vaccines, vaccinomics, immunome, nanoparticles, virus-like particles