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Vol 53(2019) N 2 p. 286-290; DOI 10.1134/S002689331902002X Full Text

N.V. Andreeva1, K.V. Zotov2, V.I. Yusupov2, A.V. Belyavsky1*

Hydrogen Sulfide Donor NaHS Protects Mesenchymal Stem and Melanoma Cells from the Negative Effects of Infrared Laser Irradiation

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
2Institute of Photon Technologies, Federal Research Center of Crystallography and Photonics, Russian Academy of Sciences, Troitsk, Moscow, 108840 Russia

*abelyavs@yahoo.com
Received - 2018-09-17; Revised - 2018-11-13; Accepted - 2018-11-14

We have established earlier that 835-nm infrared laser irradiation results in a dose-dependent growth inhibition of human mesenchymal stem and melanoma cells and is able to induce cell death. In this work we have demonstrated that hydrogen sulfide donor NaHS is able to protect both cell types from the negative action of laser irradiation and the magnitude of protection depends on NaHS concentration. The mechanism of cell protection by NaHS is primarily attributable to its effects on intracellular processes occurring after irradiation, since the protective effect does not depend on whether NaHS is added before or after irradiation. Moreover, NaHS is able to exert its protective effect even when added 6 hours post irradiation.

hydrogen sulfide, infrared laser irradiation, melanoma, mesenchymal stem cells, cytotoxicity



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