2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 53(2019) N 2 p. 267-273; DOI 10.1134/S002689331902016X Full Text

H.F. Wang1,3, Y.Z. Jiang1, L.Q. Ren2, X.B. Liu1, H.X. Zhang1, X.M. Hu1,2*

The Role of Soluble HLA-G in the Vertical Transmission of Toxoplasma gondii

1Department of Immunology, Binzhou Medical University, Yantai, Shandong Province, 264003 China
2Medical and Pharmaceutical Research Center, Binzhou Medical University, Yantai, Shandong Province, 264003 China
3Department of Immunology, Shandong College of Traditional Chinese Medicine, Yantai, Shandong Province, 264003 China

Received - 2018-04-03; Revised - 2018-07-14; Accepted - 2018-07-17

Soluble human leukocyte antigen G (sHLA-G) plays a key role in pregnancy through interaction with decidual natural killer (dNK) cell inhibitory receptors at the maternal-fetal interface. To demonstrate the possible role of sHLA-G during the pregnancy with Toxoplasma gondii infection, we compared the concentration of a murine functional homolog of sHLA-G, Qa-2, in T. gondii infected and non-infected pregnant C57BL/6 mice, and that of sHLA-G in BeWo culture supernatant. In addition, the levels of KIR2DL4 expressed on human dNK cells and NKG2A in pregnant mice were evaluated. We showed that T. gondii infection result in significant increase in the level of Qa-2 and NKG2A in pregnant mice. sHLA-G and KIR2DL4 in human samples were also significantly upregulated under the condition of T. gondii infection. The further treatment with sHLA-G antibody could reduce the expression level of KIR2DL4 which was upregulated by T. gondii infection. In summary, sHLA-G could upregulate the expression level of KIR2DL4 which lead to excessive immunological tolerance, and further contributed to T. gondii immunity escaping and affecting fetus via vertical transmission which may lead to adverse outcomes.

sHLA-G, Qa-2, KIR2DL4, NKG2A, Toxoplasma gondii, vertical transmission, adverse pregnant outcome