2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 49(2015) N 2 p. 195-216; DOI 10.1134/S0026893315020120 Full Text

B.V. Titov1,2, N.A. Matveeva1,2, M.Yu. Martynov1, O.O. Favorova1,2*

Ischemic stroke as a complex polygenic disease

1Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, 117997 Russia
2Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, 121552 Russia

Received - 2014-09-26; Accepted - 2014-09-26

Cerebrovascular accidents (strokes) are a challenge to modern health care throughout the world because they contribute greatly to morbidity, disability, and mortality rates. Ischemic stroke constitutes the majority of cases of cerebrovascular accidents. It is a complex multifactorial polygenic disease, i.e., it develops under the influence of conventional risk factors and the genetic component. The latter is formed by the joint contribution of many independent or interacting polymorphic genes. Current studies of the genetic susceptibility to ischemic stroke use two approaches based on the analysis of the association between polymorphic sites of the genome and the disease, including the candidate-gene approach and genome-wide association studies, followed by a meta-analysis of the results. This review considers the published data on genetic susceptibility to ischemic stroke, which may be a starting point for the investigation of molecular mechanisms that determine the pathophysiology of ischemic stroke. Although some progress has been made in this field, the problem of identifying genetic risk factors that could be used as markers for predicting individual susceptibility to ischemic stroke is still far from a complete solution. The main obstacle to this is the low replication of the results. It can be overcome by investigating ethnically uniform populations and clinically distinct IS forms.

ischemic stroke, complex disease, polygenic disease, atherosclerosis, genetic susceptibility, genome-wide association study, genome, human, single nucleotide polymorphism, locus, association, risk factor