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Vol 48(2014) N 6 p. 845-851; DOI 10.1134/S002689331406020X Full Text

M.-L. Xiao1, J.-Q. Liu2, C. Chen1*

Effect of tumor necrosis factor-related apoptosis-inducing ligand on developing human oligodendrocytes in culture

1Department of Neonatology, Children's Нospital of Fudan University, 399, Wanyuan Road, Shanghai, 201102 China
2Department of Neonatology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201102 China

*chaochen6010@163.com
Received - 2014-02-20; Accepted - 2014-04-21

Accumulating evidence suggests that proinflammatory cytokines play an important role in white matter injury in preterm infants, a condition in which oligodendrocyte (OL) progenitor cells are preferentially injured. We investigated the role of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its death (TRAIL-R1, TRAIL-R2) and decoy (TRAIL-R3, TRAIL-R4) receptors in periventricular white matter injury (PWMI). We hypothesized that the maturation-dependent vulnerability of OLs to TRAIL is due to the differential TRAIL receptor expression. We previously investigated TRAIL/TRAIL receptor expression levels in rat OLs in vivo in the context of PWMI. We found that during different developmental stages, human OLs differentially express TRAIL receptors; and there is a progressive loss of sensitivity to TRAIL as OLs proceed through the maturation process. Our results show that both TRAIL-R1 and -R2 are highly expressed on human OL progenitors and pre-OLs, while TRAIL-R3 and TRAIL-R4 are mainly expressed on immature and mature human OLs. Our results suggest that TRAIL-R1 and TRAIL-R2 might mediate the death signal in human OL precursor cells and pre-OLs.

oligodendrocyte, TNF-related apoptosis-inducing ligand, white matter injury



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