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Vol 48(2014) N 5 p. 718-726; DOI 10.1134/S0026893314050161 Full Text

K.S. Vishnyakova1, M.A. Babizhayev2, A.M. Aliper3,4, A.A. Buzdin3,4,5, A.V. Kudriavtseva1, Y.E.Yegorov1,6*

Stimulation of Cell Proliferation by Carnosine: Cell and Transcriptome Approaches

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
2Helmholtz Moscow Research Institute of Eye Diseases, 105062 Russia
3Rogachev Center of Pediatric Hematology, Oncology, and Immunology, 117997 Russia
4Pathwaypharmaceuticals, Limited, Hong Kong SAR
5Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia
6Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region 141700 Russia

*yegorov58@gmail.com
Received - 2014-03-28; Accepted - 2014-04-25

The concentration of the endogenous dipeptide carnosine reaches tens of millimoles in human muscle tissue. Vast data on various carnosine functions have accumulated over more than 100 years of research, the anti-aging effect being thought the most important. The effect of carnosine was studied in cultured cells. Apart from the well-known effects of increasing the Hayflick limit and causing morphological rejuvenation of cells, carnosine was found to stimulate cell divisions in the colony formation assay and to inhibit the cell transition to quiescence. A transcriptome analysis showed that carnosine-induced changes are mainly related to the positive regulation of the cell cycle at all of the levels from the onset of DNA synthesis to chromosome condensation. It was assumed that the cell cycle-stimulating potential underlies the rejuvenating effect of carnosine and that high carnosine concentrations in muscle tissue are necessary for the recovery (regeneration) of muscles after intense exercise apart from their role as a physiological buffer.

carnosine, proliferation, human cells, fibroblasts, regeneration, muscle tissue, transcriptome



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