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Vol 48(2014) N 5 p. 694-700; DOI 10.1134/S0026893314050185 Full Text

L.-G. Yin1, Z.-Q. Zou2, H.-Y. Zhao3, C.-L. Zhang4, J.-G. Shen5, L. Qi5, M. Qi6, Z.-Q. Xue7*

Analysis of Tissue-Specific Differentially Methylated Genes with Differential Gene Expression in Non-Small Cell Lung Cancers

1Department of Thoracic Surgery, Jinan Central Hospital affiliated to Shandong University, Jinan, 250013, China
2Department of Thoracic Surgery, General Hospital of Jinan Military Command, Jinan, 250013, China
3Department of Pediatrics, Jinan Central Hospital affiliated to Shandong University, Jinan, 250013, China
4Department of Cardiovascular Surgery, Jinan Central Hospital affiliated to Shandong University, Jinan, 250013, China
5Department of Emergency, Jinan Central Hospital affiliated to Shandong University, Jinan, 250013, China
6Department of Digestive System, Jinan Central Hospital affiliated to Shandong University, Jinan, 250013, China
7Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, 100853, China

*zhikaixu@hotmail.com
Received - 2014-02-28; Accepted - 2014-04-02

Adenocarcinoma (ADC) and squamous cell carcinomas (SCC) are two subtypes of non-small cell lung carcinomas which are regarded as the leading cause of cancer-related malignancy worldwide. The aim of this study was to detect the differentially methylated loci (DML) and differentially methylated genes (DMGs) of these two tumor sets, and then to illustrate the different expression levels of specific methylated genes. Using the TCGA database and Illumina HumanMethylation27 arrays, we first screened the DMGs and DML in tumor samples. Then, we explored the Biological Process terms of hypermethylated and hypomethylated genes using Functional Gene Ontology (GO) catalogues. Hypermethylation intensively occurred in the CpG-island, whereas hypomethylation was located in the non-CpG-island. Most SCC and ADC hypermethylated genes involved GO function of DNA dependent regulation of transcription, and hypomethylated genes mainly enriched in the term of immune responses. Additionally, the expression levels of specific differentially methylated genes are distinct between ADC and SCC. It was concluded that ADC and SCC have a different methylation status that might play an important role in carcinogenesis.

adenocarcinoma, squamous cell carcinomas, hypermethylation, hypomethylation



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