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Vol 48(2014) N 5 p. 664-670; DOI 10.1134/S0026893314050173 Full Text

E.N. Voropaeva1*, М.И. Воевода1, T.I. Pospelova2, V.N. Maksimov1

Linkage Disequilibrium and Haplotypes of the rs1042522, rs1625895, and rs1787862 Markers of TP53 in Patients with Diffuse Large B-Cell Lymphoma

1Institute of Internal and Preventive Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, 630089 Russia
2 Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, 630091 Russia

*vena.81@mail.ru
Received - 2014-03-27; Accepted - 2014-04-17

The association of the rs1042522, rs17878362, and rs1625895 polymorphisms of TP53 with risk of non-Hodgkin's lymphoma (NHL) has not been studied in full detail. NHL has many variants, and each individual polymorphism exerts only a minor effect, requiring the polymorphisms to be studied for particular histological subtypes of lymophomas and as components of haplotype groups. The objective of this work was to analyze the frequencies and linkage disequilibrium for rs1042522, rs1625895, and rs17878362 and their combined haplotype in patients with diffuse large B-cell lymphoma (DLBCL) and control subjects. Differences in linkage disequilibrium structure were observed for rs17878362, rs1042522, and rs1625895 in the Siberian population. The haplotype proved to be more informative than the individual TP53 polymorphisms in a case-control association analysis in DLBCL. Haplotype wArgG was associated with predisposition to DLBCL, while haplotypes wProG and dupProG were found to exert a protective effect. The effect of the haplotype at three TP53 polymorphisms was observed to vary depending on their homozygous or heterozygous state

TP53 gene, haplotype, single nucleotide polymorphism, predisposition, diffuse large B-cell lymphoma, genotyping



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