JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 48(2014) N 5 p. 634-637; DOI 10.1134/S0026893314050045 Full Text

M.J. Ghorbani1, Z. Salehi2*, E.Eskafi Sabet2, F. Ejtehadi3

Analysis of HSPA1B A1267G Gene Polymorphism in Peptic Ulcer

1Department of Biology, International Pardis, University of Guilan, Rasht, 1914, Iran
2Department of Biology, Faculty of Sciences, University of Guilan, Rasht, 1914, Iran
3Internal Medicine Department, Shiraz University of Medical Sciences, Shiraz, Iran

*geneticzs@yahoo.co.uk
Received - 2014-02-26; Accepted - 2014-03-25

Peptic ulcer disease (PUD) is a common illness, affecting a considerable number of people world-wide, and its occurrence can be influenced by environmental and genetic factors. Heat shock proteins (HSPs) function mostly as molecular chaperones, and are induced by various stresses. The A to G transition at position 1267 of the HSPA1B gene was shown to correlate with changes in the level of HSPA mRNA expression. Here, the relation between A1267G polymorphism of the HSPA1B gene and risk of peptic ulcer in the Iranian population was evaluated. One hundred subjects, who underwent gastroscopy, took part in the study. DNA samples extracted from the biopsy tissues were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). After gastroscopy, peptic ulcer was diagnosed for 50 patients; among them the distribution of AA/AB/BB genotypes was 10, 88, and 2%, respectively. As for the other 50 subjects (without peptic ulcer) included in the control group, the AA/AB/BB genotypes were identified as 40, 52 and 8%, respectively. A significant association was found between the HSPA1B genotype and peptic ulcer (6.76 OR; 95% CI, 2.26 - 20.2; p = 0.0006). Thus, the HSPA1B A1267G polymorphism may be a marker of susceptibility to peptic ulcer.

peptic ulcer diseases, HSPA1B, polymorphism



JMB-FOOTER RAS-JOURNALS