2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 45(2011) N 6 p. 911-920;
A.S. Karunas1*, Y.Y. Fedorova1, G.F. Gimalova1, N.N. Ramazanova2, L.L. Gurieva2, L.A. Muchtarova2, S.Z. Zagidullin2, E.I. Etkina2, E.K. Khusnutdinova1

Genome-Wide Association Study of Bronchial Asthma in the Volga-Urals Region of Russia

1Institute of Biochemistry and Genetics, Ufa Scienific Centre, Russian Academy of Sciences, Ufa, 450054, Russian Federation Russia
2Bashkir Medical State University, Ufa, 450000, Russian Federation Russia

Received - 2011-05-06; Accepted - 2011-05-31

Bronchial asthma is a chronic inflammatory respiratory disease caused by a complex interaction of environmental influences and genetic susceptibility. The first genome-wide association study of bronchial asthma discovered a significant association between single nucleotide polymorphisms (SNPs) located within the genomic region 17q12-q21 and childhood bronchial asthma in individuals of European descent. This result was later replicated in a number of independent population samples of European and Asian origin. Here we report the results of the first genome-wide association study of bronchial asthma in the Volga-Urals region of Russia. The study involved 358 unrelated patients with physician-diagnosed bronchial asthma and 369 disease-free control subjects of different ethnicity (Russians, Tatars, and Bashkirs). DNA specimens were genotyped using an Illumina Human610 quad array as a part of the GABRIEL project (EC contract no.LSHB-CT-2006-018996). After QC filtering procedures, a final set of 550 915 SNPs genotyped in 330patients and 348 controls was tested for association with bronchial asthma. Five markers on chromosome 17q12-21 showed significant association with bronchial asthma (p < 4.79 10-7). The rs7216389 SNP located in GSDMB intron 1 showed the strongest evidence for association (p = 1.01 10-7). Association with childhood asthma (p = 1.97 10-6 for rs7216389) was stronger than with late-onset asthma (p = 1.8 10-4 for rs7216389). A replication study of three SNPs located within GSDMB confirmed association only with childhood asthma. In sum, these results suggest that genetic variants of 17q12-q21 play an important role in susceptibility to bronchial asthma in the Volga-Urals region of Russia.

genome-wide association study, bronchial asthma