JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 44(2010) N 3 p. 393-400;
D.S. Solov'eva1, Е.В. Балановская1, M.A. Kuznetsova1, O.A. Vasinskaya1, S.A. Frolova1, E.A. Pocheshkhova2, I.V. Evseeva3, M.N. Boldyreva4, O.P. Balanovsky1*

The Russian Gene Pool: the Gene Geography of Alu Insertions (ACE, APOA1, B65, PV92, TPA25)

1Research Center for Medical Genetics, Moscow, 115478, Russia
2Kuban State Medical Academy, Maikop, 350063, Russia
3Northern State Medical University, Arkhangelsk, 163000, Russia
4Institute of Immunology Federal Medico-Biological Agency, Moscow, 115478, Russia

*balanovsky@inbox.ru
Received - 2009-10-28; Accepted - 2009-11-30

For the first time, an analysis of five Alu insertion loci (ACE, APOA1, B65, PV92, TPA25) has been carried out in 10 Russian populations (1088 individuals) covering the whole historical area of the Russian ethnos. Depending on the locus, Russian populations exhibit similarity to their Western (European populations) or Eastern (populations of the Ural region) neighbors. Considering the frequencies of the studied Alu-insertions, the Russian gene pool exhibits low variation: average interpopulation variation (d) was 0.007, whereas on classical markers, mtDNA and Y chromosome, heterogeneity of the Russian gene pool is essentially higher (0.013, 0.033, 0.142, respectively). Therefore, on the intra-ethnic level, this set of five Alu insertions has low variation. However, a clear pattern was obtained in inter-ethnic comparison of 13 East European ethnic groups, which formed three clusters in accordance with their historical and geographical position: East Slavic, Caucasian and South Ural clusters. The obtained data confirm the efficiency of using Alu insertions for studying genetic differentiation and gene pool history of East European populations.

Alu insertions, polymorphisms, Russian populations



JMB-FOOTER RAS-JOURNALS