JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 44(2010) N 3 p. 343-357;
E.B. Menshikova*, V.O. Tkachev, N.K. Zenkov

Redox-Dependent Signaling System Nrf2/ARE in Inflammation

Center of Clinical and Experimental Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, 630117, Russia

*lemen@soramn.ru
Received - 2009-07-14; Accepted - 2009-09-17

The Nrf2 transcription factor plays a key role in cell defense against oxidative stress, as well as in counteracting the chemical and physical factors that induce apoptosis and carcinogenesis. The review considers the mechanism of the Nrf2/ARE redox regulation and ARE-mediated gene expression. Special attention is paid to the anti-inflammatory effects of the Nrf2/ARE system, which are especially distinct in Nrf2 knockout animals.

transcription factors, Nrf2, ARE, oxidative stress



JMB-FOOTER RAS-JOURNALS