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Vol 47(2013) N 5 p. 645-654;
A.G. Soboleva, S.A. Brouskin, A.A. Nikolaev, V.V. Sobolev, A.V. Mezentsev*

Role of Receptor for Advanced Glycation End-Products in Pathogenesis of Psoriasis

Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991 Russia

*mesentsev@vigg.ru
Received - 2013-04-22; Accepted - 2013-04-30

This review summarizes the existing knowledge regarding the role of receptor for advanced glycation end products in pathogenesis of psoriasis. This receptor plays a crucial role in the inflammatory response. By interacting with multiple ligands and activating several signaling mechanisms, receptor for advanced glycation end products regulates gene expression via a group of well-characterized transcription factors, such as NFkB and AP1. The expression of receptor for advanced glycation end products in both immune cells and their targets, a high stability of this receptor in complexes with ligands as well as a positive feedback loop, upregulating the expression of its certain ligands, suggest receptor for advanced glycation end products as a possible principal factor that promotes the development of psoriasis. Considering receptor for advanced glycation end products as a potential master regulator of several processes that play a crucial role in development of psoriatic plaques, we believe that further experimental studies are needed to elucidate how exactly this receptor converts a transient inflammatory reaction to a sustainable inflammatory response. These studies are also needed for the development of novel medications that target receptor for advanced glycation end products and signaling mechanisms that this receptor activates.

RAGE, psoriasis, NFkB, AP1, immune response, alternative splicing



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