Vol 44(2010) N 2 p. 228-232;
A.G. Nikitin1, E.Y. Lavrikova1, Y.A. Seregin1, L.I. Zilberman2, N.M. Tsitlidze2, T.L. Kurayeva2, V.A. Peterkova2, I.I. Dedov2, V.V. Nosikov1*
Association of the Polymorphisms OF THE ERBB3 AND SH2B3 Genes with Type 1 Diabetes1State Research Center GosNIIgenetika, Moscow, 117545, Russia
2Scientific Center of Endocrinology, Moscow, 117036, Russia
Received - 2009-08-24; Accepted - 2009-09-29
To study the association with diabetes mellitus type 1, we analyzed the distribution of allele and genotype frequencies of polymorphic marker rs2292239 of ERBB3 gene, encoding epidermal growth factor receptor type 3 and polymorphic marker rs3184504 of SH2B3 gene, encoding adaptor protein LNK. The study included groups of T1DM patients and unrelated controls of Russian origin. Genotyping was performed using RFLP and real-time amplification methods. No statistically significant association with type 1 diabetes was found for the polymorphic marker rs2292239 of ERBB3, while the analysis of the distribution of allele and genotype frequencies of the polymorphic marker rs3184504 of SH2B3 gene revealed the association with T1DM in the Russian population.
type 1 diabetes mellitus, polymorphic markers rs2292239 of ERBB3 gene and rs3184504 of the SH2B3 gene, functional polymorphism Trp262Arg