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Vol 45(2011) N 2 p. 258-262;
E.P. Demina1*, V.V. Miroshnikova1, T.I. Rodygina1, P.S. Kurianov2, A.G. Vinogradov3, A.D. Denisenko3, A.L. Schwarzman1

ABCA1 Gene Expression in Peripheral Blood Lymphocytes and Macrophages in Patients with Atherosclerosis

1Konstantinov Petersburg Nuclear Physics Institute, Gatchina, 188300 Russia
2Pavlov State Medical University, Saint-Petersburg, 197089 Russia
3Saint-Petersburg Institute of Experimental Medicine RAMS, Saint-Petersburg, 197376 Russia

*citritt@gmail.com
Received - 2010-03-01; Accepted - 2010-05-04

ABCA1 transporter is known to play an important role in cholesterol transport from peripheral tissues. However, its contribution to atherosclerosis development remains obscure. Using Real Time PCR, we detected a significant reduction of ABCA1 mRNA level in leukocytes of patients with atherosclerosis compared to control. Mean ABCA1 expression levels in leukocytes from the group of patients and from the control group were 0.57 ± 0.28 and 0.93 ± 0.14 (p = 0.02). At the same time, we revealed a significant increase of ABCA1mRNA level in macrophages of patients compared to control. Mean ABCA1expression levels in macrophages from the group of patients and from the control group were 1.32 ± 0.10 and 0.90 ± 0.14 (p = 0.014). In summary, we suggest that the expression level of ABCA1 gene may regulate atherosclerosis development.

atherosclerosis, reverse cholesterol transport, macrophage, ABCA1 transporter



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