Vol 42(2008) N 5 p. 762-772;
V.P. Shirinsky, A.Yu. Khapchaev, O.V. Stepanova
Molecular mechanisms of cardiomyogenesis and the prospects for cardiomyocyte regeneration in cardiac failureRussian Cardiology Research and Production Center, Moscow, 121552, Russia
Received - 2008-04-01; Accepted - 2008-04-01
The review briefs the current state of research in molecular biological and cell aspects of cardiac development and the prospects of applying the corresponding results to treating heart failure by cardiomyocyte regeneration in damaged myocardium.
Cardiomyogenesis, higher vertebrates, cardiogenic mesoderm, master genes, signaling cascades, transcription factors, contractile system, cardiomyocyte proliferation and hypertrophy, stem cells, cell therapy, cardiac failure