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Vol 42(2008) N 5 p. 720-728;
M.I. Shadrina, P.A. Slominsky

Mitochondrial dysfunction and oxidative damage in the molecular pathology of Parkinson's disease

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia
Received - 2008-04-02; Accepted - 2008-04-02

Parkinson's disease is a complex disorder that is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Its development is determined by the interaction between the genetic constitution of a body and environmental factors. Analysis of the genes associated with monogenic forms of Parkinson's disease implicated proteasomal degradation, differentiation of dopaminergic neurons, mitochondrial dysfunction, and oxidative damage in its pathogenesis. The review considers ample data that suggest a key role for mitochondrial dysfunction and oxidative stress.

Parkinson's disease, dopaminergic neurons, mitochondrial dysfunction, oxidative damage



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