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Vol 48(2014) N 2 p. 227-237; DOI 10.1134/S002689331402006X  G.F. Gimalova1*, A.S. Karunas1,2, Yu.Yu. Fedorova1, E.R. Gumennaya3, S.V. Levashova4, Z.R. Khismatullina4, E. Prans5, S. Köks5, E.I. Etkina4, E.K. Khusnutdinova1,2 Association of Polymorphisms in the Toll-Like Receptor Genes with Atopic Dermatitis in the Republic of Bashkortostan 1Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, 450054 Russia;2Bashkir State University, Ufa, 450074 Russia 3Dermatovenerological Dispensary of the Republic of Bashkortostan, Ufa, 450027 Russia 4Bashkir State Medical University, Ufa, 450000 Russia 5University of Tartu, Tartu, 50411 Estonia *galiyagimalova@gmail.com Received - 2013-09-12; Accepted - 2013-09-17 Atopic dermatitis is a common chronic inflammatory skin disease and depends on the interaction between environmental factors and genetic predisposition. A considerable role in allergic disorders is played by polymorphisms of the genes of pattern recognition receptors (PRRs), which recognize conserved standard molecular structures (patterns) unique to large pathogen groups. Polymorphisms of several PRR genes, including the genes of Toll-like receptors (TLR1, TLR2, TLR4, TLR5, TLR6, TLR9 , and TLR10 ), NOD-like receptors ( NOD1 and NOD2), and a lipopolysaccharide receptor (CD14) along with C11orf30 and LRRC32 from chromosome 11q13.5, were studied in atopic dermatitis patients and control subjects from Bashkortostan. TLR1 (rs5743571 and rs5743604), TLR6 (rs5743794), and TLR10 (rs11466617) polymorphisms were associated with atopic dermatitis. The results supported the idea that innate immunity and polymorphisms of the TLR2-family genes play a substantial role in atopic dermatitis. Mycobacterium tuberculosis, multidrug and extensive drug resistance, multiplex PCR, hybridization, oligonucleotide microchip |
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