JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 42(2008) N 5 p. 699-709;
N.L. Lazarevich1, D.V. Alpern1,2

Hepatocyte nuclear factor 4 in epithelial development and carcinogenesis

1Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia
2Biological Faculty, Moscow State University, Moscow, 119992, Russia
Received - 2008-04-02; Accepted - 2008-04-02

Hepatocyte nuclear factors (HNFs) play a key role in the establishment and maintenance of hepatocyte differentiation. Not only do HNFs control the expression of functional liver-specific genes, but they are also involved in regulating cell proliferation, morphogenesis, and detoxification in the liver. The review considers the main biological properties of HNF4α, the central regulator of hepatocyte differentiation; the patterns of its expression during embryo development and in adult tissues; the mechanisms regulating its activity and transcriptional properties; and the essential target genes. Studies of gene expression with rodent experimental models of carcinogenesis and clinical samples of human hepatic tumors revealed that transcriptional repression of HNF4α is associated with progression and dedifferentiation of tumors of this type. The possibility of a reversion of the dedifferentiated malignant phenotype by means of exogenous HNF4α expression confirms the important role of HNF4α in coordinating cell proliferation, differentiation, and the maintenance of epithelial morphology in epithelial cells of several types.

hepatocyte nuclear factor 4α, differentiation, hepatocyte, liver, transcription regulation, tumor progression, hepatocellular carcinoma, epithelial-mesenchymal transition



JMB-FOOTER RAS-JOURNALS