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Vol 42(2008) N 1 p. 123-126;
B.N. Goldstein, A.M. Aksirov, D.T. Zakrjevskaya

A simple kinetic model for dynein oscillatory activity

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia
Received - 2007-07-03; Accepted - 2007-07-27

A kinetic model was proposed for dynein, a motor protein, complexed with microtubule fragments. The model explains the experimental observations of oscillatory movements in surprisingly simple axoneme fragments perfused with an ATP solution. This is the first model explaining the oscillatory activity of dynein as determined by a cooperative interaction of two dynein heads in the axoneme. The oscillation shape, frequency, and amplitude obtained for the model are close to the corresponding parameters determined experimentally.

Dynein, axoneme, kinetic model, oscillations



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