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Vol 42(2008) N 1 p. 98-104;
E.N. Voronina1, T.D. Kolokoltsova2, N.M. Slinko3, E.A. Nechaeva2, M.L. Filipenko1

Transcription factor YY1 is involved in activation of transcription of the human gene for ribosomal protein L11

1Institute of Chemical Biology and Fundamental Medicine, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090, Russia
2Institute of Cell Culture, VECTOR State Research Center of Virology and Biotechnology, Kol'tsovo, Novosibirsk region, 630559, Russia
3Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090, Russia
Received - 2007-01-17; Accepted - 2007-04-23

Apart from its function during translation, human ribosomal protein L11 plays a role in regulating the cell cycle. Changes in transcription of its gene (HRPL11) can be involved in the cell cycle control and ribosome assemblage. To study the mechanisms regulating the HRPL11 expression, the interaction of HRPL11 promoter elements with nuclear extract proteins obtained from different cells was examined. Using oligonucleotide competitors containing known transcription factor-binding sites and polyclonal antibodies, it was shown that transcription factor YY1 participated in the regulation of HRPL11 transcription in all cell lines under study. Comparison of the sets of proteins binding to the HRPL11 promoter for rapidly growing cells, normal cell lines, and cells repressed by serum deprivation indicated that YY1 probably activates HRPL11 transcription.

ribosomal proteins, human cell lines, transcription factors



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