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Vol 42(2008) N 1 p. 9-19;
S.N. Tamkovich1,2, V.V. Vlassov1, P.P. Laktionov1

Circulating DNA in the blood and its application in medical diagnosis

1Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia
2Novosibirsk State University, Novosibirsk, 630090, Russia
Received - 2007-02-19; Accepted - 2007-04-03

Circulating nucleic acids were discovered more than 30 years ago, but did not attract much attention until the past decade. This review summarizes the data on the sources of extracellular DNA circulating in the blood, features of its circulation, and pathways of its removal. The possibility of using circulating DNA in medical diagnosis is discussed.

circulating DNA, apoptosis, necrosis, active secretion, nucleases, early noninvasive diagnosis of cancer



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