2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 46(2012) N 5 p. 613-626;
S.V. Ulyanov1,2, A.A. Gavrilov1,3*

Chicken β-Globin Genes: A Model System to Study the Transcriptional Regulation at the Level of Genome Domains

1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia
2Moscow State University, Biology faculty, Moscow, 119992 Russia
3Center for Medical Research, University of Oslo, Moscow, 119334 Russia

Received - 2011-12-16; Accepted - 2012-02-10

In the last quarter of the 20th century, studies with a number of model systems produced a hypothesis that the higher eukaryotic genome consists of functionally isolated areas termed genomic domains. Each domain includes one or more genes and a regulatory system that is normally active only for the given domain and allows it to achieve a regulatory autonomy of the neighboring chromosome regions. A genome domain is characterized by spectra of covalent histone modifications, which determine the domain boundaries and the extent of chromatin condensation within the domain, thus determining whether transcriptional activation is possible for the domain genes. The domain hypothesis of genome organization is due, to a large extent, to studies of the mechanisms regulating transcription of the globin genes in vertebrates. The chicken β-globin gene domain is one of the most popular models in the field. The model was used to investigate the basic principles of the complex function of higher eukaryotic enhancers, the properties of insulators and functional units of eukaryotic enhancers and promoters, the influence of covalent histone modifications on the extent of chromatin condensation, and the role of such modifications in regulating transcription within the domain. The review summarizes the data on the chicken β-globin gene domain and considers the domain hypothesis of eukaryotic genome organization.

β-globin gene domain, transcription, chromatin, locus control region