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Vol 59(2025) N 1 p. 17-25; DOI 10.1134/S0026893324700687  E.O. Aristova1, I. A. Volkhin1,2*, A.A. Denisova1, P.A. Nikitin1,3, E.R. Petrukhin1 De Novo Gene Birth 1Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, 119234 Russia2Life Sciences Research Center, Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow oblast, 141700 Russia 3Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071 Russia *ilyavolkhin2@gmail.com Received - 2024-06-25; Revised - 2024-06-25; Accepted - 2024-06-25 According to classic ideas, new genes emerge from old genes by duplication or horizontal transfer. Analyses of a large number of genomes in recent decades have shown that some genes have no visible homologs and have presumably emerged de novo from previously noncoding sequences. The review considers possible mechanisms of de novo gene formation, the properties of protein sequences encoded by such genes, and features of their expression and selection. The problem of identification of de novo arising gene is discussed separately. de novo gene, orphan gene, pervasive transcription, pervasive translation |
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