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Vol 58(2024) N 5 p. 822-835; DOI 10.1134/S0026893324700390  G.A. Shilovsky1,2*,** p62: Intersection of Antioxidant Defense and Autophagy Pathways 1Biological Faculty, Moscow State University, Moscow, 119991 Russia2Kharkevich Institute of Information Transmission Problems, Russian Academy of Sciences, Moscow, 127051 Russia *gregory_sh@list.ru **grgerontol@gmail.com Received - 2024-02-21; Revised - 2024-04-20; Accepted - 2024-05-07 Numerous regulatory cascades link the cell response to oxidative stress and the mechanisms that maintain homeostasis and cell viability. The review summarizes the molecular mechanisms of interaction of the autophagy protein p62 with cell defense systems, primarily through the NRF2/KEAP1/ARE pathway. Understanding the cross-regulation of antioxidant defense and autophagy pathways contributes to the search for promising molecular targets to prevent and treat age-related diseases NRF2, p62, autophagy, regulatory loop, KEAP1, aging, sestrins |
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