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Vol 55(2021) N 6 p. 847-853; DOI 10.1134/S0026893321050125  Y.S. Stafeev1, E.K. Shevchenko1, M.A. Boldireva1, D.N. Penkov1* Possible Role of Prep 1 Homeodomain Transcription Factor in Cardiac Mesenchymal Stromal Cells 1National Medical Research Center of Cardiology, Ministry of Health of Russian Federation, Moscow, 121552 Russia*dpenkov@yahoo.com Received - 2020-06-18; Revised - 2021-05-11; Accepted - 2021-05-11 Homeodomain transcription factors play a significant role in mesenchymal stromal cells (MSCs). Previously, the role of Meis1, Pbx1 and Prep1 proteins from the TALE (Three Amino acid Loop Extension) family in adipocytic and osteogenic differentiation of mouse mesenchymal stromal cells was established. In this work, using ChIP-seq and bioinformatic analysis we investigated the binding pattern of PREP1 with the genomic DNA of human heart MSCs, identified nearby genes, and analyzed their ontology. The target genes of the PREP1 factor in cardiac MSCs have been established. Based on the results, the possible involvement of transcription factor PREP1 in the direct reprogramming of fibroblasts into cardiomyocytes is discussed. cardiomyocyte, mesenchymal stromal cells, transcription factor, PREP1 |
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