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Vol 54(2020) N 5 p. 623-632; DOI 10.1134/S0026893320050039  D.V. Glazkova1,2, F.A. Urusov1,2*, E.V. Bogoslovskaya1, G.A. Shipulin1 Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection 1Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal Medical-Biological Agency of the Russian Federation, Moscow, 119992 Russia2Izmerov Research Institute of Occupational Health, Moscow, 105275 Russia *flanger.fx@mail.ru Received - 2020-03-19; Revised - 2020-04-14; Accepted - 2020-04-16 It is commonly known that the antiviral activity of the TRIM5α protein, the intracellular retrovirus restriction factor, underlies the resistance of the Old World monkeys to HIV-1. This fact suggests that TRIM5α can potentially be used to cure HIV-1 infection in humans. The present review considers the mechanisms of HIV-1 replication inhibition by the TRIM5a protein and the prospects for using it in gene therapy of HIV infection. TRIM5α, HIV-1, gene therapy |
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