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Vol 43(2009) N 2 p. 284-300; Yu. M. Yevdokimov, V. I. Salyanov, S. G. Skuridin From liquid crystals to DNA nanoconstructions Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, RussiaReceived - 2008-07-09; Accepted - 2008-07-09 This paper reviews the data obtained in our laboratory on the physicochemical properties of liquid-crystalline dispersions formed by double-stranded nucleic acids (DNA and RNA) and the specific features of their behavior in quasinematic layers. The basic data obtained in this field have been used as the background for elaboration of the DNA nanoconstructions carrying various guest molecules (chemical substances or biologically active compounds). Two theoretically feasible approaches to designing DNA nanoconstructions are compared. The unique properties of these nanoconstructions determining the area of their application are described. Nanobiotechnology, nucleic acids, DNA liquid-crystalline dispersions, complex formation, DNA nanoconstructions, circular dichroism, biosensing unit, analyte, hydrogel, rare earth elements, nonviral delivery systems |
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