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Vol 43(2009) N 2 p. 232-240; M.M. Kurshakova1, E.N. Nabirochkina1,2, S.G. Georgieva1,2,3 E(y)2, a novel component of the eukaryotic SAGA/TFTC complex, is involved in mRNP export from the nucleus and couples transcription with the nuclear pore 1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia2Center for Medical Studies, University of Oslo, Moscow, 119334, Russia 3Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia Received - 2008-10-03; Accepted - 2008-10-03 For many years, transcription was studied independently of the following steps of gene expression. A tight connection between different steps of gene expression became evident in recent years. This review discusses the new molecular mechanisms that coordinate transcription and mRNA export from the nucleus and couple transcription and the position of the gene in the nucleus. The new E(y)2 protein, which plays an important role in these processes, is described. SAGA/TFTC complex, protein E(y)2, insulator Su(Hw), protein Xmas-2, transcription, RNA export, nuclear pore, eukaryotes |
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