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Vol 46(2012) N 2 p. 322-327; D.G. Naumoff1,2* Furanosidase Superfamily: Search of Homologues 1S.N. Winogradsky Institute of Microbiology, Russian Academy of Sciences, Moscow, 1173122State Research Center GosNIIGenetika, Moscow, 117545 Russia *daniil_naumoff@yahoo.com Received - 2011-06-01; Accepted - 2011-07-06 The furanosidase superfamily contains the GH32, GH43, GH62, GH68, GH117, DUF377 (GH130), and DUF1861 families of glycoside hydrolases and their homologues. Catalytic domains of these families have five-bladed β-propeller tertiary structure. Iterative screening of the protein database supports of their relationship as well as evolutionary connections with domains from GH33 and GH93 families of glycoside hydrolases. The latter two have the structure of the six-bladed β-propeller. Among detected homologues we found 441 unclassified proteins. These proteins are combined into 39 groups based on homology: FURAN1- FURAN39. FURAN8 and FURAN36 can be considered as separate subfamilies within the GH43 and GH32 families of glycoside hydrolases, respectively. The remaining 37 groups are new families of hypothetical glycoside hydrolases. glycoside hydrolase, furanosidase, FURAN families, new protein families, furanosidase superfamily, PSI-BLAST, PSI Protein Classifier, CAZy, β-propeller, hierarchical protein classification, protein evolution, search of homologues, gene annotation< |
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