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Vol 49(2015) N 4 p. 471-479; DOI 10.1134/S0026893315040081  O.I. Kit, D.I. Vodolazhsky* Molecular biology of colorectal cancer in clinical practice Rostov Research Institute of Oncology of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, 344037 Russia*dvodolazhsky@gmail.com Received - 2014-11-20; Accepted - 2014-11-22 The review summarizes current data on the molecular genetic mechanisms underlying the pathogenesis of colorectal cancer (CRC) and addresses the connections between these mechanisms and biomarkers used for predictive diagnosis, risk stratification, prognosis, and predicting response to chemotherapy and tar-geted therapy. Evidence of microRNA involvement in the regulation of major signaling pathways affected by CRC pathogenesis is discussed, and signaling pathways that can be used as targets in the therapy of colorectal cancer are examined. colorectal cancer (CRC), biomarker, targeted therapy, signaling pathway, microRNA, EGFR, KRAS, microsatellite instability, chromosomal instability, CIMP, TGF-ß, WNT |
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